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KMID : 0545119950050010031
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Journal of Microbiology and Biotechnology
1995 Volume.5 No. 1 p.31 ~ p.35
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Isolation and Properties of Antitumor Antibiotic YS-1649 from Penicillium sp. strain 1649
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Yoo Seong-Jae
Park Boo-Kil
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Abstract
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An antitumor antibiotic named YS-1649 was isolated from the culture filtrate of a newly isolated fungus identified as Penicillium sp.. The fermentation yield reached about 40㎎ per liter of the broth.
YS-1 649, a γ-lactone - structured antibiotic, has the molecular fomular of C_7H_6O_4. Its structure was determined to be patulin by spectral analysis. It is active against some bacteria and showed cytotoxic effect on the proliferation of human breast cancer cell line, MCF-7, at concentrations of more than 0.048㎍/㎖. This compound also showed strong cytotoxic effect on the proliferation of human cancer cell lines, A549 and ACHN.
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